Sr. Research Associate, Functional Genomics

Full Time

South San Francisco, California, United States

Job description

Scismic is supporting the growth of a biotech company that is translating genetic insights into therapeutic advancements.

We are seeking an exceptional, hands-on researcher to join our functional genomics team and contribute to advancing our functional screening for genetic modifiers. The successful candidate will work with Senior Scientist to execute cellular assays and engineer cell models for relevant disease indications. As this team is at the core of our early research, the successful candidate will collaborate with multi-disciplinary scientists for target discovery, being a key contributor generating functional genomics data. The role is hands on in nature and requires a detail-oriented mindset and a curious, motivated disposition to accomplish experiments.

Your role:

  • Design, optimize, and execute cellular assays to enable high throughput functional genomics screening aimed at identifying novel genetic modifier targets.
  • Engineer cell models in disease-relevant systems for hit validation
  • Perform mechanism of action studies, including analysis of protein levels, gene expression, and pathway activity to validate and advance functional genomics targets.
  • Collaborate closely with colleagues on our therapeutic area teams to develop assay strategies for primary screens and secondary assays.
  • Independently summarize, analyze, and regularly present work internally and externally.
  • Contribute to development of automated processes, data analysis methods, and advanced assay technologies.

Your Navigation Tools:

  • BS/MS in a Biology related field and at least 3-10 years of relevant experience
  • Broad laboratory experience and skills in molecular and cell biology (DNA/RNA extraction, PCR/qPCR, FACs, NGS library prep, etc.)
  • Expertise in cell-based assay development using a variety of readout technologies such as luciferase, ELISA/immuno-assays, and qPCR/ddPCR gene expression-based assays
  • Expertise in mammalian cell culture is required; experience with genetic perturbation of mammalian cells (CRISPR, RNAi, ASO, lentiviral cell engineering, etc.) is strongly preferred
  • Experience with arrayed screening and comfort with laboratory automation is preferred.
  • Experience with iPSC-derived cell models is a plus
  • Strong experimental design, troubleshooting, and data analysis skills
  • Excellent communication, presentation, collaboration, and organizational skills to work as part of a team.
  • Proven ability to think critically, adapt to new data, multi-task, and work in a fast-paced environment

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