(Senior) Computational Biologist

Full Time

New York City, New York, United States

Sponsors work visa for candidates.

Job description

Scismic is supporting the growth of an early-stage, venture-backed biotech company in New
York City!

This company engineers synthetic regulatory elements that solve expression issues for therapeutic nucleic acids (gene therapy, gene editing, mRNA). This technology is critical for genetic medicine to address vastly more conditions. To do that, we work at the interface of genomics, machine learning, and synthetic biology. If you share our enthusiasm with working on a fascinating problem at the intersection of synthetic biology and machine learning, that will significantly impact millions of patients, come join us!


Role

As Computational Biologist, you are the connective tissue between the wet and dry lab. You will design DNA libraries, analyze sequencing data, and build predictive models of genetic regulation.

Responsibilities

  • Design DNA libraries for massively parallel reporter assays.
  • Develop computational models of gene regulation.
  • Analyze NGS data and AI models generated in our wet lab.
  • Bring in-house a variety of relevant datasets (ENCODE, single-cell atlases, etc).
  • Work hand in hand with scientists at the bench, to ensure a close coupling between experimental and computational approaches.
Qualifications

  • PhD or equivalent in bioinformatics, computational biology or related field.
    • Senior: 5+ years leading research teams, as a postdoc or in industry.
  • Expertise in mammalian gene regulation.
  • Experience with NGS and genomics datasets, including
    • working with public datasets (e.g., ENCODE, single-cell atlases, GTEx, etc),
    • knowledge of state-of-the-art computational biology methods and packages.
  • Experience working successfully in collaborative, multidisciplinary teams.
  • Desire to work in a rapidly growing company, and a fast-changing environment.
Desirable plus

  • Familiarity with data analysis environments such as Python or R, and/or experience collaborating with computational scientists.
  • Experience with MPRAs, and/or single cell RNA-seq.
  • Experience building deep learning models.

Life with our company

In this formative stage of the company, you will have a large impact on many of the key decisions that will define our long-term path. You will join a team of curious and creative experts passionate about making a difference for patients. You will help shape a diverse and inclusive culture, with competitive benefits including great healthcare, generous time off, flexible hours, and access to a 401(k).

Our lab is in the heart of SoHo, NYC, but if you don't need to be at the bench you can work from wherever you please.

If you share our enthusiasm with working on a fascinating problem at the intersection of synthetic biology and machine learning, that will significantly impact millions of patients, come join us!

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