Senior Scientist, Assay Development

Full Time

Lexington, Massachusetts, United States (This job is on-site)

Job description

Scismic is supporting the growth of a biotech company Lexington, MA that is advancing drug discovery through its small molecule directed evolution platform!

The company is dedicated to accelerating small molecule discovery by combining massively parallel bench science and computation. Their technology rapidly analyzes 100-1000x more compounds than traditional methods by using a variety of DNA Encoded Libraries and applying machine learning to design high throughput follow-on experiments. By adopting a tightly coupled, iterative cycles of computational and bench science we reduce the cost of early stage drug discovery while tackling hard, medically relevant targets.

You’ll own:
  • Assay development and optimization for biochemical assays (e.g. TR-FRET, Luminescence, AlphaELISA) to establish in vitro pre-cell activity and kinetics of small molecule drug candidates with recombinant protein
  • Generate key data to drive SAR and portfolio decision making
  • Coordination with other members on the biology and automation teams regarding assay development and execution

You’ll assist:
  • Optimizing protein constructs which will be suitable for potential assays
  • Development of mass spectrometry-based assays
  • Coordination with CROs for outsourcing of assays

Skills & expertise you have:
  • Bachelor’s degree with 10-13 years industry experience, Master’s degree with 5-7 years industry experience, or a PhD with 0-3 years industry experience
  • Expertise in biochemical recombinant in vitro assays to study ****the activity of small molecules (e.g. TR-FRET, Luminescence, AlphaELISA, kinetic analysis, mass spectrometry)
  • Ability to manage several projects at the same time
  • Translating and troubleshooting assays in the literature to be functional in-house
  • Experience with HTS platforms
  • Proficiency with automated liquid handlers

Skills & expertise you can learn:
  • How to work with affinity-based screening platforms
  • How to coordinate with and manage relationships with CROs
  • How to effectively work as a key member of matrix teams and drive projects through matrix leadership

Within 1 month, you’ll…
  • Build foundational knowledge of what is done within the company as well as with current portfolio
  • Learn assay methods, practices for data processing, and efforts towards automating lab work from our current team
  • Provide suggestions or thoughts on current processes in order to improve our operations

Within 3 months, you’ll…
  • Establish plans for assays of upcoming assays
  • Coordinate with the team for when compounds will be available and when assays will be run
  • Make decisions on compounds to move forward for additional testing

Within 6 months, you’ll…
  • Own biochemical assay plans for the company’s target focused projects
  • Establish timelines and coordinate assay development/optimization in alignment with a project timeline
  • Aid in establishing constructs which will be valuable for in vitro work

Within 12 months, you’ll…
  • Provide guidance for the compute team towards generating standard data analysis workups
  • Explore technology development ideas towards integrating biochemical assays in other aspects of the the company's platform

Benefits and perks:
  • Healthcare/Dental/Vision insurance plans, with premiums 100% covered for employees and 50% covered for dependents.
  • FSA and HSA programs.
  • 401k program.
  • Equity compensation.
  • Unlimited vacation policy.
  • Annual professional development budget for all employees.

The company is currently a distributed company with physical locations in San Francisco and Boston. They support remote work, but strongly prefer a continental US timezone.

The health and safety of employees are a priority. All employees are required to be Fully Vaccinated against COVID-19 in order to work onsite. If hired, candidates must present proof of vaccination on a confidential basis prior to their scheduled start date confirming that they have completed the COVID-19 vaccination process, subject to any written request for medical or religious accommodation and to the extent permitted by applicable law.

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