Scientist - Tissue Engineering

Full Time

Woburn, Massachusetts, United States

Job description

Scismic is supporting the growth of a biotech company that is developing organ-on-a-chip technology!

The tissue engineering team is seeking an experienced and motivated individual for the role of Scientist. The tissue engineering team is responsible for developing complex human in vitro models (CIVM) which recapitulate the phenotypic and molecular functions that are important to drug discovery and development. The successful candidate will be responsible for applying their scientific experience with advanced in vitro tissue culture and engineering towards expanding our absorption, metabolism, distribution, and excretion (ADME) modeling capabilities.

Responsibilities

  • Apply tissue engineering principles to developing and implementing state-of-the-art advanced culture models/CIVM in the field of drug metabolism.
  • Independently design and execute studies, analyze and interpret data, and present findings back to the project team.
  • Analyze and interpret data, including quantitative, physiologically relevant readouts from CIVM using immuno-, biochemical, and bioanalytical assays.
  • Collaborate and communicate data clearly and concisely within a multidisciplinary team, including tissue engineering, cell biology, systems pharmacology, and systems biology

Qualifications

  • PhD degree in Biological Engineering, Bioengineering, Chemical Engineering, or a related discipline with 0+ years of relevant experience,  MS degree with 2+ years of relevant experience, or BS with 2+ years of hands-on lab experience working with primary human tissue culture. Appointment level will depend on skill set and years of experience.
  • Outstanding laboratory technique: primary human cell culture; fluorescence microscopy, RT-PCR, immuno-, biochemical & bioanalytical assays.
  • Detail-oriented, organized, and scientifically driven with solid reasoning skills in experimental design, data analysis, and interpretation.
  • Experience developing and working with advanced tissue culture systems including microphysiological systems, tissue chips, organ-on-chips, 3D cultures
  • Excellent written and verbal communication skills; ability to follow complex instructions, multitask, carefully document work in written records.
  • Strong data analysis and statistical skills are required (e.g., Prism, MATLAB, R-studio etc.)
  • Able to work well under direction as well as independently; self-motivated and able to work as a team in a multidisciplinary, fast-paced, dynamic, and results-oriented environment.

Bonus Qualifications

  • Experience with ADME relevant cultures (liver, GI tract, kidney, skeletal muscle, adipose) is a plus!
  • Experience with pharmacology studies with complex in vitro models is a plus!

Compensation: We offer a compensation package that includes a competitive salary based on experience, full health insurance, company contribution for dental and vision insurance, company match 401(k), and stock options.

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