Director of Antibody Discovery and Molecular Biology

Full Time

Cambridge, Massachusetts, United States (This job is on-site)

Sponsors work visa for candidates.

Job description

Scismic is supporting the growth of biotech startup developing bispecific antibodies for cancer therapy.


The company is currently seeking a motivated, experienced and collaborative leader in biologics discovery and development, to be responsible for implementation and optimization of state-of-the-art antibody (protein) platforms, design and generation of innovative lead candidates, propose and advance projects from initiation to lead identification and IND filing. In addition, the successful candidate will:



  • Lead antibody discovery, engineering and molecular biology teams responsible for designing, generating and characterizing antibody-based therapeutics.
  • Lead pipeline candidates from discovery to lead candidate selection and contribute to downstream development toward IND.
  • Design and execute engineering campaigns, including complex multi-specific antibody campaigns.
  • Lead technology development in antibody selection, engineering and molecular biology.
  • Develop and employ complex molecular biology workflows to rapidly generate constructs from a variety of in silico and biological sources.
  • Interact and collaborate with leaders and teams across antibody optimization and protein sciences on project delivery and new technology development.
  • Partner with Business Development to pursue new partnerships.
  • Represent the scientific goals and interests at scientific conferences, partner meetings and other events.
  • Establish a network of external partners from academia and industry to strengthen capabilities and capacity
  • Develop and manage operating budget.
  • Recruits and develops an antibody team, fosters a culture of innovation that cultivates teamwork and improves performance.


  • PhD in a relevant scientific area, such as antibody discovery or protein engineering, protein biochemistry or biotechnology, plus a minimum of 10 years of professional experience in biologics research.
  • Working experience in diverse antibody discovery methods using animal immunization and/or in vitro methodologies including rapid work-flows for lead selection based on predetermined criteria.
  • Working experience using molecular biological methods for creating novel therapeutics from individual antibody and other protein binding components.
  • In-depth knowledge of downstream development to IND and Clinical development.
  • Recognized leader in antibody/protein engineering and molecular biology as evidenced by publications, participation in international conferences, membership on journal editorial boards, etc.
  • Excellent communicator and highly effective in interacting with key internal and external stakeholders.
  • Ability to establish high-level strategies for new drug technologies and apply new technologies to drug discovery.
  • Team player and builder, possess great coaching skills and has great organizational skills.
  • High degree of integrity and professionalism.
  • High functioning in an environment dedicated to exceptional quality and integrity.
  • Proficiency in Microsoft Office, and other programs necessary for the position.
  • Experience with NGS and/or antibody display platforms preferred.


Hhighly competitive salaries and comprehensive benefits, including medical and dental insurance, paid time off, and 401(k) with a generous company match.


  • 401(k) matching
  • Flexible spending account
  • Relocation assistance
  • Stock options


  • Monday to Friday

Ability to Relocate

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