Scientist / Sr. Scientist: Antibody Engineer

Full Time

Allston, Massachusetts, United States

Job description

Scismic is supporting the growth of a biotech company in Allston, MA!

We are seeking an enthusiastic, creative Scientist / Sr. Scientist: Antibody Engineer to join their growing team in their mission of multiplexed, in vivo drug discovery!
 
The ideal candidate will have extensive experience in protein engineering and protein therapeutic design. This is a unique opportunity to own impactful projects and play a big role on a small team looking to redefine current drug discovery paradigms. You will play an integral part in every step of our programs’ work, from designing initial binder campaigns to reformatting hits, advancing candidates through screening funnels, and nominating candidates for clinical development. In particular, you will make use of high-throughput and library methods both in vitro and, uniquely, in vivo using the company's proprietary technology.

You will work closely with a collaborative, interdisciplinary team of scientists to design, execute, and analyze complex experiments in a fast-paced environment. There will be many opportunities for creativity, innovation, and ownership in this hands-on role leveraging our cutting edge platform to initiate and advance programs. 

Responsibilities

  • Independently design, plan and execute experiments to advance drug candidates and programs
  • Assume ownership of protein engineering efforts for at least one drug program
  • Build on current binder discovery and screening pipelines to increase throughput and efficiency
  • Balance responsibilities across initiating and advancing programs and pursuing long-term innovation projects
  • Contribute to lead validation experiments and prepare preclinical data packages
  • Stay up to speed on cutting edge research and industry standards for protein therapeutics
  • Maintain data integrity and effectively communicate findings to the team

Required Qualifications

  • PhD in protein biochemistry, molecular biology, cell biology, bioengineering or similar; or B.S./M.S. with at least 4 years experience
  • Hands on expertise in protein engineering with a libraries/selections/multiplexing/empirical approach
  • Established experience in advanced cloning techniques
  • Proven track record of solving difficult scientific problems
  • Collaborative, curious, and flexible, with a genuine passion for innovative science and developing medicines


Preferred Qualifications

  • PhD with 3+ years experience in pharma/biotech industry working on protein or cell-based drug program(s)
  • Expertise in protein engineering in the context of antibody constructs, single-domain antibodies, or similar
  • Experience in designing libraries for binder campaigns, epitope selection, choice of format, linker design, avidity engineering, structure-guided engineering, etc.
  • Experience with yeast display or other display technology i.e. phage display, mammalian display or ribosome display
  • Experience in designing and running high throughput screening assays
  • Experience with CAR-T, T-cell engagers, multi-specifics, ADCs, targeted cytokines, or other ‘targeted-effector’ modalities
  • Knowledge of cell biology and cancer biology is a plus

Why you might be a good fit

  • Highly independent, productive, and creative scientist able to confront obstacles to drive projects forward
  • Team player with enthusiasm for working closely with a tight-knit team on challenging problems
  • Strong oral and written communication to facilitate complex experiments with multiple parties; excellent record keeping
  • Forethought, organization, and flexibility to meet deadlines and iterate in a fast-paced environment

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