Senior Research Scientist - Formulation

Full Time

Cambridge, Massachusetts, United States

Job description

Scismic is supporting the growth of a biotech startup in Boston, MA developing a drug delivery platform to convert injectable therapies into oral modalities.  

Job Summary

They are hiring a Senior Research Scientist to aid in the formulation of our novel oral products focusing on biologics (e.g., proteins), but also small molecules and nucleic acids. This position will work within a small, multi-functional research team to move products from Discovery through Pre-clinical phases, and support CMC, clinical and IND activities. The qualified candidate will possess state-of-the-art expertise related to formulation production theories, principles, methods and techniques for targeted delivery of proteins. They will be involved in planning and execution of developmental programs for a wide variety of pipeline products. They will keep up with the latest information about the trends, improvement methods, and functions of currently used pharmaceutical drugs. 

Primary Responsibilities

  • Formulation of orally delivered biologic drugs
  • Executing appropriate investigational procedures that are pertinent to the reactions, composition, relationships, structure, and properties of the compounds and products
  • Identifying new techniques, tools, and procedures to analyze formulations while making use of various methods such as titration, FT-IR, HPLC, etc., to identify the material and chemical characteristics of the formulation substances
  • Supporting the development of products through CMC by preparing quality assurance documentation including formulation specifications
  • Conducting in vitro and in vivo (small animal) studies to test formulations


  • PhD in pharmaceutical science, biological/chemical engineering, or a related field and at least five years of hands-on industry experience in protein or similar biologic drug formulation is required. 
  • Demonstrate in-depth knowledge about the basic and advanced concepts related to materials science and pharmaceutical development and familiarity with the pertinent analysis techniques. 
  • An independent worker and self-starter who is dependable, articulate, accurate, and mature. 
  • Flexibility and the ability to multi-task is key to working in a fast-paced and constantly evolving start-up environment.  
  • Solid written and verbal skills and the ability to maintain laboratory records are crucial. Strong teamwork, interpersonal and observational skills are required. 

Other Information

  • Lift/push/pull up to 25 pounds
  • Work safely with chemicals, drugs and standard laboratory equipment
  • Wear protective clothing including masks and gloves
  • Occasionally work on weekends or holidays

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